The usage rate of GLP-1 medications, such as Ozempic, Mounjaro, Wegovy, and Zepbound, among adults in the United States reaches about one in every eight people. These medications are used for treating diabetes and weight loss and have now coincided with religious holidays like Yom Kippur, which will take place from the evening of September 20 to the evening of September 21, 2026.
Fasting Challenges for GLP-1 Medication Users
Fasting on Yom Kippur means abstaining from food and drink for about 25 hours, which can have significant effects on individuals' metabolism. GLP-1 medications help lower blood sugar and reduce appetite by mimicking a natural gut hormone. However, these medications also come with common side effects like nausea and dehydration, which may be exacerbated by fasting.
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For this reason, individuals planning to fast for Yom Kippur should have a more careful plan. In particular, increasing the dosage of medications or starting new medications should be done at least two weeks prior to this day to minimize side effects.
Key Tips for Fasters
If GLP-1 medications are administered via weekly injections, patients should adhere to their schedule and avoid changing or skipping their dose on Yom Kippur. If daily injections coincide with fasting, it is advisable to administer the injection before breaking the fast to prevent gastrointestinal side effects.
For diabetic patients, fasting may increase the risk of low blood sugar, especially if they are taking other medications that lower blood sugar. In such cases, consulting with a doctor to adjust the dosage and timing of medications is important.
Overall, patients should consult with their doctor before fasting and ensure they consume a balanced meal containing protein before starting the fast. This can help reduce side effects and make fasting safer for them.
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